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SERVIKAL INTRAEPITELIAL BACHADON NEOPLAZIYASI BO'LGAN BEMORLARDA MOLEKULYAR GENETIK POLIMORFIZMLAR
Maqola haqida umumiy ma'lumotlar
Servikal intraepitelial servikal neoplaziya (CIN) butun dunyo bo'ylab ayol aholi orasida juda keng tarqalgan patologiya hisoblanadi [3,6,7]. Ma'lumki, CIN shakllanishi va boshlanishi inson papillomavirusi (HPV) [3,4] infektsiyasiga tegishli bo'lgan bir qator omillarning murakkab o'zaro ta'sirini keltirib chiqaradi. Biroq, barcha holatlarda HPV infektsiyasi CIN boshlanishiga yordam bermaydi, bu H. Bai, H. Yin (2020) ning xorijiy tadqiqotchilariga ko'ra, patologiyaning rivojlanishi ko'p jihatdan turli genlarning faoliyatiga bog'liq [1,5].
1. Bai, H., & Yin, H. (2020). Engeletin suppresses cervical carcinogenesis in vitro and in vivo by reducing NF-κB-dependent signaling. Biochemical and Biophysical Research Communications. doi:10.1016/j.bbrc.2020.03.091, M.C.A. Westin, et al., Expression of VEGF-A in intraepithelial and invasive cervical neoplasia, J. Cytol. Histol. 3 (2) (2015)].
2. Brusselaers, N., Shrestha, S., Van De Wijgert, J., & Verstraelen, H. (2018). Vaginal dysbiosis, and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. doi:10.1016/j.ajog.2018.12.011
3. Cancer Genome Atlas Research Network, Integrated genomic and molecular characterization of cervical cancer, Nature 543 (7645) (2017) 378.
4. Liman Yang1, Jing Jin1, Juhong Liu //Correlation of MMP2-C1306T (rs243865) and MMP7-181A/G (rs11568818) with cervical cancer: a meta-analysis. European Journal of Gynaecological Oncology 2020, Vol. 41 Issue (4): 508-512
5. Seliakova M.S., Ageeva T.A., Savchenko S.V. Relationship between metalloproteinase and TIMP1 expression and intensity of cervical inflammatory reaction in women of different age groups with cervical intraepithelial neoplasia and microinvasive carcinoma// Siberian Journal of Oncology. 2019; 18(6): 50–56. – doi: 10.21294/1814-4861-2019-18-6-50-56.
6. Shuchi Shukla, Sabuhi Qureshi, Uma Singh, and Sanjay Khattri. A Study of Matrix Metalloproteinase-2 and Interleukin-18 in Preinvasive and Invasive Lesions of Cancer Cervix // J Midlife Health. 2020 Oct-Dec; 11(4): 236–239.
7. Vandooren J., van den Steen P.E., Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (gelatinase B/MMP-9): The next decade. Crit Rev Biochem Mol Biol. 2013 May-Jun; 48(3): 222–72. doi: 10.3109/10409238.2013.770819.
Aliyeva , D. A., Xolmurodova , A. S., & Boboyev , Q. . (2022). SERVIKAL INTRAEPITELIAL BACHADON NEOPLAZIYASI BO'LGAN BEMORLARDA MOLEKULYAR GENETIK POLIMORFIZMLAR. Academic Research in Educational Sciences, 3(6), 824–833. https://doi.org/
Aliyeva , Dilfuza , et al. “SERVIKAL INTRAEPITELIAL BACHADON NEOPLAZIYASI BO'LGAN BEMORLARDA MOLEKULYAR GENETIK POLIMORFIZMLAR.” Academic Research in Educational Sciences, vol. 6, no. 3, 2022, pp. 824–833, https://doi.org/.
Aliyeva , A., Xolmurodova , S., and Boboyev , . 2022. SERVIKAL INTRAEPITELIAL BACHADON NEOPLAZIYASI BO'LGAN BEMORLARDA MOLEKULYAR GENETIK POLIMORFIZMLAR. Academic Research in Educational Sciences. 6(3), pp.824–833.